# Your Questions About SPINRAZA Answered
Keywords: SPINRAZA, SMA, survival motor neuron, antisense oligonucleotide, lumbar puncture, clinical trial, real-world evidence, dosing, administration, safety profile

> This page provides detailed information about SPINRAZA, including its mechanism of action, safety profile, efficacy data, administration, dosing schedule, and available support materials for healthcare professionals and patients.

## Details
- [What is SPINRAZA?](#): SPINRAZA is an antisense oligonucleotide designed to increase functional survival motor neuron protein.
- [Who can receive SPINRAZA?](#): SPINRAZA is indicated for 5q SMA Types I, II, and III patients, as recommended by NICE.
- [When was SPINRAZA approved in the UK?](#): SPINRAZA was approved in Europe in 2017 and has treated over 13,000 patients globally.
- [How does SPINRAZA work?](#): SPINRAZA targets SMN2 pre-mRNA to enhance the production of functional SMN protein.
- [What is SPINRAZA’s safety profile?](#): SPINRAZA is well-tolerated with an acceptable benefit-risk profile, though adverse reactions from lumbar puncture have been observed.
- [What efficacy data is there to support SPINRAZA?](#): Clinical trials and real-world evidence demonstrate sustained efficacy across ages and SMA types.
- [What real-world evidence is there to support the use of SPINRAZA?](#): Real-world studies show disease stabilization and motor function improvements in SMA patients treated with SPINRAZA.
- [How is SPINRAZA administered?](#): SPINRAZA is administered intrathecally via lumbar puncture by trained healthcare professionals.
- [How often is SPINRAZA administered?](#): SPINRAZA requires 4 loading doses followed by maintenance doses every 4 months.
- [What support materials are available for healthcare professionals prescribing SPINRAZA?](#): Healthcare professionals can access downloadable materials and additional resources by contacting MedInfoUK@biogen.com.
- [What support materials are available for patients receiving SPINRAZA?](#): Patients can access support materials by contacting MedInfoUK@biogen.com or their local area care manager.
- [Who can I contact for help prescribing SPINRAZA?](#): For assistance, contact MedInfoUK@biogen.com or your local area care manager.